TOSYMRA™ delivers the
efficacy of an injection
with the convenience of a nasal spray.
TOSYMRA offers migraine relief in a portable nasal spray for treatment at home, at work, or while traveling
TOSYMRA is self-administered by patients
- TOSYMRA is a novel nasal spray formulation of sumatriptan 10 mg developed with Intravail® technology1,2
- TOSYMRA with Intravail®, n-Dodecyl beta-D-maltoside or DDM, allows efficient transmucosal absorption of sumatriptan and has demonstrated a significantly improved PK profile compared to sumatriptan 20-mg nasal spray (Imitrex®)1,2
- Intravail® technology enables transient permeation enhancement that is demonstrated safe and non-irritating3,4
IMPORTANT SAFETY INFORMATION
TOSYMRA is contraindicated in patients with ischemic Coronary Artery Disease (CAD) or coronary artery vasospasm (including Prinzmetal’s angina); Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders; history of stroke or transient ischemic attack or history of hemiplegic or basilar migraine; peripheral vascular disease; ischemic bowel disease; uncontrolled hypertension; severe hepatic impairment.
Please see full Prescribing Information for the complete list of Contraindications.
References: 1. Munjal S, Gautam A, Offman E, Brand-Schieber E, Allenby K, Fisher DM. A randomized trial comparing the pharmacokinetics, safety, and tolerability of DFN-02, an intranasal sumatriptan spray containing a permeation enhancer, with intranasal and subcutaneous sumatriptan in healthy adults. Headache. 2016;56(9):1455-1465. 2. TOSYMRA [package insert]. Maple Grove, MN: Upsher-Smith Laboratories, LLC; 2019. 3. Lipton RB, Munjal S, Brand-Schieber E, Rapoport AM. DFN-02, Sumatriptan 10 mg Nasal Spray with Permeation Enhancer, for the Acute Treatment of Migraine: A Randomized, Double-Blind, Placebo-Controlled Study Assessing Functional Disability and Subject Satisfaction with Treatment. CNS Drugs. 2019;33(4):375-382. 4. Maggio ET. Absorption enhancing excipients in systemic nasal drug delivery. J Excipients and Food Chem. 2014;5(2):100-112.