Tosymra® is indicated for the acute treatment of migraine with or without aura in adults.

Limitations of Use: Use only if a clear diagnosis of migraine has been established. Tosymra is not indicated for the prevention of migraine or treatment of cluster headache.

Tosymra is contraindicated in patients with a history of hemiplegic or basilar migraine. This is not the only contraindication for Tosymra.

Fast, ready-to-use migraine pain relief1-3

10 minutes

Tosymra delivers migraine pain relief in as little as 10 minutes with just one spray for some patients (13% vs. 5% for placebo).*1-3

Efficacy of Tosymra is based on relative bioavailability to subcutaneous sumatriptan at a dose of 4 mg. In a clinical study, this dose of sumatriptan resulted in 57% of patients achieving pain relief at 2 hours vs. 21% for placebo.1

*Time to onset and degree of pain relief varies by patient.

About Tosymra
intravail

Tosymra uses the science of Intravail®

Tosymra is the first and only triptan nasal spray to use the novel ingredient Intravail® to enhance drug absorption across the nasal mucosa.4

How It Works

Tosymra for free†

The Access Pathways® Program is a best-in-class savings and support program. Access Pathways®, in partnership with Blink Pharmacy Plus, offers:

Eligible patients pay $0† per prescription, per month, renewable annually

Optional free
home delivery

Dedicated customer support to guide you and your patients through the process

Savings Program

†Restrictions apply. Platinum Pass® savings card or filling prescription through Blink Pharmacy Plus required. Maximum of eight single-dose nasal spray units per month. Medicare, Medicaid, and other federal and state healthcare program patients are not eligible.

Tosymra is simple to administer

See the Instructions for Use.

Single-use, 10 mg dosage

Fine mist-like spray

Discreet size can be
taken anywhere

Learn more

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References

  1. Tosymra [package insert]. Maple Grove, MN: Upsher-Smith Laboratories, LLC: 2019.
  2. Mathew NT, et al. Dose ranging efficacy and safety of subcutaneous sumatriptan in the acute treatment of migraine. US Sumatriptan Research Group. Arch Neurol. 1992;49(12):1271-1276.
  3. Wendt J, et al. A randomized, double-blind, placebo-controlled trial of the efficacy and tolerability of a 4-mg dose of subcutaneous sumatriptan for the treatment of acute migraine attacks in adults. Clinical Therapeutics. 2006;28(4):517-526.
  4. Maggio ET. Intravail®: highly effective intranasal delivery of peptide and protein drugs. Expert Opinion Drug Delivery. 2006;3(4):529-539.