10 minutes

Tosymra delivers migraine pain relief in as little as 10 minutes with just one spray for some patients (13% vs. 5% for placebo).*1-3

Give your patients options

Oral therapy may not be the optimal treatment for every migraine. See why Tosymra uses the novel ingredient Intravail®.

Tosymra achieved peak plasma concentration

8x faster than Imitrex® nasal spray4

Mean sumatriptan plasma concentration-time profile

Results from a randomized, crossover, pilot pharmacokinetic study conducted in 18 healthy adults.4 In this study, three AEs occurred with Tosymra (vomiting, paresthesia and burning sensation in nose). Three AEs occurred with Imitrex® (sumatriptan) 20 mg nasal spray (nausea and throat irritation [two events]). All events were mild or moderate in intensity.5

intravail

Tosymra uses the science of Intravail®

Tosymra is the first and only triptan nasal spray to use the novel ingredient Intravail® to enhance drug absorption across the nasal mucosa.6

Controlled transient permeation of the nasal mucosa6

Intravail® is thought to facilitate paracellular absorption by transiently relaxing tight junctions, allowing drug access to systemic circulation, among other mechanisms.6-8

Nasal mucosa

Tosymra is a sumatriptan nasal spray with mist-like administration

The safety profile of Tosymra is generally consistent with that of subcutaneous injectable sumatriptan.

ADVERSE REACTIONS:

Most common adverse reactions (≥5% and > placebo) with sumatriptan injection were tingling, dizziness/vertigo, warm/hot sensation, burning sensation, feeling of heaviness, pressure sensation, flushing, feeling of tightness, and numbness.

Additional common adverse reactions with Tosymra include the local irritative symptoms of application site reaction, dysgeusia, and throat irritation.

Tolerability

In a 6-month open-label, repeat-dose safety study designed to assess the safety and tolerability of Tosymra in 167 adult patients, Tosymra was well-tolerated, with a low rate of triptan-related adverse events (TEAEs).9 Over the course of the 6-month study, 3,292 doses of Tosymra were used to treat 2,211 migraine attacks.10

Most common TEAEs
(≥5% of subjects)
Patients
n(%)9
Total events
n5
Incidence per
individual dose5,9
Application site pain*51 (30.5%)56817.3%
Dysgeusia35 (21.0%)2327.0%
Upper respiratory tract infection18 (10.8%)240.7%
Nasopharyngitis12 (7.2%)130.4%
Sinusitis††11 (6.6%)120.4%
Application site reaction9 (5.4%)321.0%
  • 5 patients (3%) discontinued due to adverse events.10
  • Overall, 2.9% of doses were associated with a triptan-related TEAE.10
  • The majority of triptan-related adverse events were mild; none were severe.9

Upsher-Smith Partners in health since 1919

Redefining patient-centric treatment

Upsher-Smith Laboratories, LLC has never wavered in our desire to offer people high-quality products that could help improve their health and lives. Having served patients for over a century, we take pride in providing attentive customer service, having strong industry relationships and being dedicated to uninterrupted supply.

Making migraine our priority

A variety of dosage forms and delivery options for known and trusted molecules ensures you have a variety of medication options that can address the unique needs of patients with migraine.

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